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Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study
The optimum treatment for high-risk soft-tissue sarcoma (STS) in adults is unclear. Regional hyperthermia concentrates the action of chemotherapy within the heated tumour region. Phase 2 studies have shown that chemotherapy with regional hyperthermia improves local control compared with chemotherapy alone. We designed a parallel-group randomised controlled trial to assess the safety and efficacy of […]
Multi-targeted prevention of cancer by sulforaphane
Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake may lower overall cancer risk, including colon and prostate cancer. Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables and is especially high in broccoli and broccoli sprouts. SFN has proved to be an […]
Intravenous Ascorbate as a Chemotherapeutic and Biologic Response Modifying Agent
For over 15 years we have studied high dose intravenous ascorbic acid (IAA) as an adjunctive therapy for cancer patients. Initially, doses of 15 g per infusion were used, once or twice per week. These doses improved patient’s sense of well being, reduced pain, and in many cases prolonged life beyond prognostications of oncologists.
Results in brain tumors with locoregional RF hyperthermia in the GIMT
In contrast to the enormous therapeutic efforts, the results of conventional treatments for highly malignant brain tumors (gliomas) are rather unsatisfactory. The prognosis for this tumor type is poor, its median overall survival (6-14 months) is less than one year (1,2,5,6,8). Most of the cases are inoperable, or only partial removal is possible, and the […]
Effective Natural Remedies in Complementary Oncology
Naturopathic antineoplastic agent “artesunate” (Artemisia annua – mugwort) acts as a biological apoptosis inducer and potential anti-cancer drug. In the field of holistic, complementary cancer treatment wins the made of leaves and flowers of the one-year-old mugwort (Artemisia annua) obtained natural active ingredient artesunate an increasingly larger and important therapeutic value.
Dr. Panos T. Pappas Ph.D., Professor of Physics and Professor of Mathematics
Professor Pappas pursued post-graduate studies leading to a PhD and then pursued research in Theoretical and Mathematical Physics at the University of London, the Imperial College, Queen Elizabeth College and the Queen Mary College, Greek State Scholarship for Doctoral studies, Fulbright Scholarship for post Doctoral Research. <!–more–>
Differences in heat sensitivity between normal and acute myeloid leukemic stem cells: feasibility of hyperthermic purging of leukemic cells from autologous stem cell grafts
In autologous stem cell transplantation contamination of the graft with malignant cells is frequently noticed and necessitates the use of in vivo or in vitro purging modalities. The hematopoietic recovery after transplantation depends on the number of stem and progenitor cells in the transplant. Therefore, in the present study the effects of hyperthermic treatment on […]
